Have you had experience making changes to the database structure using migrations?

Yes, there is experience in making changes to the database structure using migrations. Migrations allow sequentially modifying the database schema, preserving the history of changes and enabling rollback. In C# with Entity Framework, migrations are created and applied using the commands:

dotnet ef migrations add AddNewColumn
dotnet ef database update

This allows adding new tables, columns, changing data types, etc., with scripts automatically generated for updating the database without data loss.